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Cefuroxime and Cefuroxime axetil
Pham P and Bartlett JG
03-16-2008
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Available formulation in Zambia: Tablets, film coated: 250 mg, 500 mg. Tablets: 125 mg, 250 mg, 500 mg. Powder for injection: 250 mg, 750 mg, 1.5 gm (as sodium salt) vial.
- Second generation cephalosporin with activity against PCN-susceptible S. pneumoniae and H. influenzae.
-
Sinusitis & acute or chronic bronchitis: 250 mg bid x 7-10 d
- Acute - uncomplicated cystitis: 125 mg 250 mg bid x 7-10 d
- Lyme disease: Adults and children over 12 years of age: 500 mg twice daily for 20 days
Zambia Information Author: Paul A. Pham Pharm.D.
- Skin soft tissue infection
- Upper respiratory infection (acute bronchitis, chronic bronchitis, acute sinusitis, chronic sinusitis, pharyngitis, tonsillitis, otitis media, epiglottis)
- Lower respiratory tract infection (pneumonia)
- Bone and joint infections (septic arthritis)
-
Gonorrhea
- Osteomyelitis
- Respiratory tract infections - lower
- Septic arthritis
-
Sinusitis
- Skin and soft tissue infections (cellulitis)
brand
name
| generic
| Mfg
| brand
forms
| cost*
|
| Ceftin | Cefuroxime axetil | ~GlaxoSmithKline | PO
tab
250mg | $5.40 |
|
|
|
| PO
tab
500mg | $9.80 |
|
|
|
| PO
tab
125mg/5mL | $2.20 per 5mL |
|
|
|
| oral
suspension
250mg/5ml | $3.75 per 5ml |
| Zinacef | Cefuroxime sodium | ~GlaxoSmithKline | IV
vial
750mg | $6.76 |
|
|
|
| IV
vial
1.5g | $13.44 |
|
|
|
| IV
vial
7.5g | $65.95 |
*Prices represent cost per unit specified and are representative of "Average Wholesale Price" (AWP).
AWP Prices were obtained and gathered by Lakshmi Vasist Pharm D using the Red Book, manufacturer's
information, and the McKesson database.
^Dosage is indicated in mg unless otherwise noted.
-
Parenteral dosing: Mild to moderate infections: 0.75 gm IM or IV q8h.
- Severe infections: 1.5 gm IV q8h .
-
Oral dosing: 250-500mg PO twice daily.
- Uncomplicated GC: 1000mg x 1 (but cefixime preferred).
Usual dose.
0.75Gm-1.5Gm IV q8-12h; no dosage change for oral administration.
0.75Gm IV q24h; 250 mg PO q24h.
750mg post dialysis.
750 mg q24h.
No data. Consider 1.5gm IV q12h.
- Phlebitis at infusion sites.
- Allergic reactions
-
Diarrhea and C. difficile colitis
- Eosinophilia
- Positive Coombs' test
- Drug fever
- CNS: convulsions (high dose with renal failure), confusion, disorientation, and hallucinations.
-
Neutropenia and thrombocytopenia
- Hepatitis
- Interstitial nephritis
- Anaphylaxis reaction
- Hemolytic anemia
Probenecid:increased cefuroxime serum concentration due to inhibition of tubular secretion by probenecid (no dose adjustment needed).
2nd generation oral and parenteral cephalosporin with convenient twice a day dosing schedule. One of the IDSA-ATS recommended 2nd generation cephalosporin for the treatment of CAP caused by PCN-susceptible S. pneumoniae.
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