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Cloxacillin
Pham P and Bartlett JG
03-19-2008
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Available formulation in Zambia: Capsule: 500 mg; 1 g (as sodium salt). Powder for injection: 500 mg (as sodium salt) vial. Powder for oral liquid: 125 mg (as sodium salt)/5 ml.
- Indicated for infections due to beta-lactamase-producing staphylococci.
- Empiric treatment for S. aureus infections: cloxacillin 2 gm IV q6h
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Cellulitis and other soft tissue infections: cloxacillin 1-2 gm IV q6h
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Diabetic foot ulcer: cloxacillin 2 gm IV q6h plus gentamicin and metronidazole.
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Septic arthritis and osteomyelitis: cloxacillin 2 gm IV q6h
Zambia Information Author: Paul A. Pham, Pharm. D.
- No longer available in the U.S.
- Staphylococcal infections
- Skin and soft tissue infections
brand
name
| generic
| Mfg
| brand
forms
| cost*
|
| Coxapen; Tegopen | Cloxacillin | No longer available in the U.S. | oral
tablet
500mg | N/A |
*Prices represent cost per unit specified and are representative of "Average Wholesale Price" (AWP).
AWP Prices were obtained and gathered by Lakshmi Vasist Pharm D using the Red Book, manufacturer's
information, and the McKesson database.
^Dosage is indicated in mg unless otherwise noted.
250-500 mg po q6h.
Usual dose
Usual dose
Usual dose
Usual regimen
Usual regimen
No data.
- Hypersensitivity reactions and rash.
- GI intolerance and diarrhea
- Drug fever
- Coombs' test positive without hemolytic anemia
- Jarisch-Herxheimer reaction (with treatment of spirochetal infections)
-
C. difficile -associated colitis
- LFT elevation s
- Anaphylaxis
- Hemolytic anemia
- Thrombocytopenia
- Leukopenia
- Interstitial nephritis
Tetracyclines :in vitro antagonism when co-administered. Bactericidal effect of penicillins may be diminished in vivo. Avoid co-administration.
No longer available in the U.S. QID dosing may decrease patient adherence.
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